Preclinical pharmacology

Synavia provides early drug development studies with pharmacokinetic and pharmacodynamic endpoints.

In vivo pharmacokinetics

Absolute bioavailability

PK after different dosing routes, comparative PK (rats)

Lympatic transport of drugs (rats)

PK after nebulization drug administration, local pulmonary drug effects

PK data analysis

Population PK analysis

In vivo efficacy/pharmacodynamics models

• Collagen induced arthritis (rat)
• Monoiodoacetate-induced arthritis (rat)
• Non-alcoholic fatty liver disease NAFLD/NASH

In vitro screening

In vitro screening for drug effects in several cell culture lines including primary hepatocytes, fibroblasts, chondrocytes, and PBMCs.